DOVE

This R package implements maximum likelihood methods described in Lin et al. (2021a; 2021b) for evaluating the durability of vaccine efficacy in a randomized, placebo-controlled clinical trial with staggered enrollment of participants and potential crossover of placebo recipients before the end of the trial. It has been released on CRAN.

References

1. Lin, D. Y., Zeng, D., Gilbert, P. B. (2021a). Evaluating the Long-term Efficacy of Coronavirus Disease 2019 (COVID-19) Vaccines. Clinical Infectious Diseases, ciab226, https://doi.org/10.1093/cid/ciab226.
2. Lin, D. Y., Gu Y., Zeng, D., Janes, H. E., Gilbert, P. B. (2021b). Evaluating Vaccine Efficacy Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection. Clinical Infectious Diseases, ciab630, https://doi.org/10.1093/cid/ciab630.