iDOVE

This R package implements a nonparametric maximum likelihood method described in Lin et al. (2021) for assessing potentially time-varying vaccine efficacy against SARS-CoV-2 infection under staggered enrollment and time-varying community transmission, allowing crossover of placebo volunteers to the vaccine arm. It has been released on CRAN.

References

1. Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021). Evaluating Vaccine Efficacy Against SARS-CoV-2 Infection. Clinical Infectious Diseases, ciab630, https://doi.org/10.1093/cid/ciab630.