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COVID

This R package implements the two robust methods described in Lin et al. (2023+) to assess the totality of evidence for the treatment effects on the entire clinical course of a patient using daily clinical outcomes. In addition, we develop a SAS macro that fits marginal proportional hazards models for multiple events and combines the evidence of treatment effects using the Wei, Lin and Weissfeld (1989, JASA) method.

DOVE

This R package implements maximum likelihood methods described in Lin et al. (2021a; 2021b) for evaluating the durability of vaccine efficacy in a randomized, placebo-controlled clinical trial with staggered enrollment of participants and potential crossover of placebo recipients before the end of the trial. It has been released on CRAN.

DOVE3

This R package implements the methods described in Lin et al. (2022) for estimating the time-varying effectiveness of vaccination and prior infection against COVID-19 related outcomes. It is an extension of the previous DOVE package by estimating the effects of multiple vaccine products as well as prior infection simultaneously under a single multiplicative intensity model.

iDOVE

This R package implements a nonparametric maximum likelihood method described in Lin et al. (2021) for assessing potentially time-varying vaccine efficacy against SARS-CoV-2 infection under staggered enrollment and time-varying community transmission, allowing crossover of placebo volunteers to the vaccine arm. It has been released on CRAN.

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